cell signaling transduction

Objective To study the expression of related protein of apoptosis signaling transduction induced by Fas in labial salivary gland of patients with sjogren syndrome ( pSS), and to explore the possible pathway of cell signaling transduction resulting in pSS.

目的研究原发性干燥综合症（primarySjgrengsyndrome，pSS）唇腺组织细胞中Fas介导的细胞凋亡信号转导相关蛋白的表达，探讨导致干燥综合征的细胞信号转导盼可能途径。

Methods: Firstly, a model of complex cell signaling transduction networks was constructed in terms of available cell signaling transduction pathways and the research data of the mechanisms of biochemical action among signaling molecules. Next, its topological structure properties were analyzed at several different levels.

方法：首先根据已知的细胞信号转导途径以及信号转导分子间的生化作用机制的研究结果，构建出复杂细胞信号转导网络模型，进而在此模型的基础上从不同的层次对其拓扑结构属性进行分析。

Protein phosphatase catalyzed dephosphorylation reaction, so that protein phosphorylation and dephosphorylation, terminate the transfer of signaling molecules, and thereby regulate cell signaling signal transduction pathway.

蛋白磷酸酶与蛋白激酶作为一对开关调控细胞内的一系列生化反应，蛋白磷酸酶可以催化去磷酸化反应，使磷酸化的蛋白质脱磷酸化，终止信号分子的传递，从而调控细胞信号转导通路。

Results 249 genes out of 8 192 were identified differently, at least two times. Most of the genes ( 79%) involved in cell signaling transduction, cell cycles, metabolism, inflammatory response and apoptosis, whose mRNAs were differently regulated.

结果在8192个基因中，初筛出249个（3%）表达差异达2倍以上的基因，其中主要是细胞信号和传递，细胞周期和代谢，凋亡及炎症相关类基因（占79%）。

The apoptotic agents also can transmit into the cell through cascade transduction of intracellular signaling molecules, resulting in degradation of DNA and cell apoptosis.

凋亡诱导剂需经细胞内的信息分子逐级转导才能将凋亡信号由细胞外转导入细胞内，最终降解DNA，导致细胞凋亡。

Objective: To investigate the topological structure properties of cell signaling transduction networks, in order to offer assistance for the research on the complexity of cell signaling system.

目的：探讨细胞信号转导网络的拓扑结构属性，从而为复杂性细胞信号网络系统的研究提供有益帮助。

Property and Significance of Cell Signaling Transduction Scale-Free Network

细胞信号转导网络的无尺度属性及其意义